Predicting preterm birth based on vaginal microbiota assessment by real-time PCR in the first trimester

Detecting high risk of preterm birth (PB) early makes its prevention possible. The aim the work was to develop a mathematical predictive model for assessing based on quantitative analysis vaginal microbiota in first trimester pregnancy. study included 199 pregnant women, i.e. 41 pregnancies that ended birth, and 158 — term birth. Vaginal analyzed all patients 1st pregnancy by real-time PCR (qPCR). method dicriminant used model. A predicting PB developed with calculation PRIMA prognostic index (Premature Birth. Index Of Microbiological Analysis). If value > 0 – premature is low, if < high. sensitivity specificity are respectively 70.7% 79.75%, effectiveness 77.89%. Evaluation it possible identify high-risk group perform timely preventive measures.